[Genesis 2:7 Then the Lord God formed man from the dust of the ground and breathed into his nostrils the breath or spirit of life, and man became a living being.]

Without the Holy Spirit, there is a void of emptiness in our heart that we long to be filled. Some try to fill this emptiness with alcohol, pleasure, sin, music, addictions, money and material wealth etc only to discover they are still empty. Only the Holy Spirit can give mankind satisfaction and contentment. From the above verse, we understand God formed man from the dust of the ground but man could not move or do anything, until God breathed the Spirit into His nostrils and man become a living soul. So it is the Spirit of God that made man to become a living soul. So without the Spirit, we are absolutely empty. We keep searching for fulfillment in things. You want a fulfilling life? GOD instructs us to seek to be filled with the Holy Spirit. Without being filled with the Holy Spirit, we keep searching and never find. Be filled with the Holy Spirit and you will be filled with the fullness of God and will have no room for emptiness, depression, addictions etc.